Umphumela we-bactericidal we-hyperbaric oxygen therapy ekulimaleni kokushiswa

Isingeniso

Ukulimala kokushiswa kuvame ukuhlangana nezimo eziphuthumayo futhi kuvame ukuba indawo yokungena yamagciwane. Izingozi zokusha ezingaphezu kuka-450,000 zenzeka minyaka yonke okubangela ukufa kwabantu abacishe babe yi-3,400 e-United States. Ukusabalala kokulimala kokusha e-Indonesia kungamaphesenti angu-0.7 ngo-2013. Ingxenye engaphezu kwengxenye yalokhu Ngokwezifundo eziningana eziphathelene nokusetshenziswa kweziguli zelashelwa izifo ezibangelwa amagciwane, ezinye zazo ezazingazweli kuma-antibiotic athile. Ukusebenzisai-hyperbaric oxygen therapy(HBOT) ukwelapha ukusha kunemiphumela emihle eminingana ehlanganisa nokuphatha izifo ezibangelwa amagciwane, kanye nokusheshisa inqubo yokuphola kwesilonda. Ngakho-ke, lolu cwaningo luhlose ukufakazela ukuphumelela kwe-HBOT ekuvimbeleni ukukhula kwamagciwane.

Izindlela

Lolu ucwaningo locwaningo lokuhlola onogwaja kusetshenziswa idizayini yeqembu lokulawula ngemuva kokuhlolwa. Onogwaja abangu-38 banikezwe ukushiswa kwezinga lesibili esifundeni sehlombe ngensimbi yensimbi eye yashiswa ngaphambilini imizuzu emi-3. Amasiko amagciwane athathwe ngezinsuku ezi-5 nezi-10 ngemuva kokuchayeka ekushiseni. Amasampula ahlukaniswe ngamaqembu amabili, i-HBOT nokulawula. Ukuhlaziywa kwezibalo kwenziwa kusetshenziswa indlela ye-Mann-Whitney U.

Imiphumela

Amagciwane e-Gram-negative ayeyi-pathogen etholakala kakhulu kuwo womabili amaqembu. I-Citrobacter freundi kwakuyibhaktheriya evame kakhulu e-Gram-negative (34%) etholakala emiphumeleni yesiko lamaqembu womabili.

Ngokuphambene neqembu lokulawula, kwakungekho ukukhula kwebhaktheriya okutholakala emiphumeleni yesiko leqembu le-HBOT, (0%) vs (58%). Ukunciphisa okuphawulekayo kokukhula kwebhaktheriya kubonwe eqenjini le-HBOT (69%) uma kuqhathaniswa neqembu lokulawula (5%). Amazinga ebhaktheriya amile konogwaja abayisi-6 (31%) eqenjini le-HBOT kanye nonogwaja abangu-7 (37%) eqenjini elilawulayo. Sekukonke, kwakukhona ukukhula kwamagciwane okuncane kakhulu eqenjini lokwelashwa kwe-HBOT uma kuqhathaniswa neqembu lokulawula (p <0.001).

Isiphetho

Ukuphathwa kwe-HBOT kunganciphisa kakhulu ukukhula kwamagciwane ekulimaleni kokushiswa.