Umphumela wokubulala amagciwane wokwelashwa komoya-mpilo we-hyperbaric ekulimaleni kokusha

Isingeniso

Ukulimala kokusha kuvame ukuhlangana ezimweni eziphuthumayo futhi kuvame ukuba yindawo yokungena kwamagciwane. Ukulimala kokusha okungaphezu kuka-450,000 kwenzeka minyaka yonke okubangela ukufa okucishe kube ngu-3,400 e-United States. Ukusabalala kokulimala kokusha e-Indonesia kungu-0.7% ngo-2013. Ngaphezu kwengxenye yalokhu Ngokusho kwezifundo eziningana ngokusetshenziswa kweziguli zelashelwa ukutheleleka ngamagciwane, ezinye zazo ezazingamelana nama-antibiotic athile.ukwelashwa komoya-mpilo we-hyperbaric(HBOT) yokwelapha ukusha inemiphumela eminingana emihle okuhlanganisa nokuphatha ukutheleleka ngamagciwane, kanye nokusheshisa inqubo yokuphulukisa amanxeba. Ngakho-ke, lolu cwaningo luhlose ukufakazela ukusebenza kahle kwe-HBOT ekuvimbeleni ukukhula kwamagciwane.

Izindlela

Lolu ucwaningo lokuhlola onogwaja olusebenzisa umklamo weqembu lokulawula ngemva kokuhlolwa. Onogwaja abangu-38 bashiswa ngezinga lesibili esifundeni samahlombe ngepuleti lensimbi lensimbi ebelifudunyezwe ngaphambilini imizuzu emi-3. Ukukhula kwamagciwane kwathathwa ezinsukwini zesi-5 nese-10 ngemva kokuchayeka ekushisweni. Amasampula ahlukaniswe ngamaqembu amabili, i-HBOT kanye nokulawula. Ukuhlaziywa kwezibalo kwenziwa kusetshenziswa indlela kaMann-Whitney U.

Imiphumela

Amabhaktheriya angenayo i-gram ayeyi-pathogen evame ukutholakala kuwo womabili amaqembu. I-Citrobacter freundi yayiyi-bacteria engeyona i-gram evame kakhulu (34%) etholakale emiphumeleni yokukhula kwamaqembu womabili.

Ngokungafani neqembu lokulawula, akukho ukukhula kwamagciwane okutholakale emiphumeleni yokukhula kweqembu le-HBOT, (0%) vs (58%). Ukwehla okukhulu kokukhula kwamagciwane kubonwe eqenjini le-HBOT (69%) uma kuqhathaniswa neqembu lokulawula (5%). Amazinga amagciwane amile konogwaja abayisithupha (31%) eqenjini le-HBOT kanye nonogwaja abayisikhombisa (37%) eqenjini lokulawula. Sekukonke, ukukhula kwamagciwane kube kuncane kakhulu eqenjini lokwelashwa kwe-HBOT uma kuqhathaniswa neqembu lokulawula (p < 0.001).

Isiphetho

Ukunikezwa kwe-HBOT kunganciphisa kakhulu ukukhula kwamagciwane ekulimaleni kokusha.