I-Stroke, isimo esilimazayo esibonakala ngokuncipha okungazelelwe kokunikezwa kwegazi ezicutshini zobuchopho ngenxa ye-hemorrhagic or ischemic pathology, iyimbangela yesibili yokufa emhlabeni wonke futhi iyimbangela yesithathu ehamba phambili yokukhubazeka. Izinhlobo ezimbili eziyinhloko ze-stroke ziyi-ischemic stroke (i-accounting ye-68%) kanye ne-hemorrhagic stroke (32%). Naphezu kwe-pathophysiology yabo ehlukile ezinyathelweni zokuqala, kokubili ekugcineni kuholela ekunciphiseni kokunikezwa kwegazi kanye ne-ischemia ye-cerebral elandelayo phakathi nezigaba ze-subacute nezingapheli.
I-Ischemic Stroke
I-Ischemic stroke (AIS) iphawulwa ukuvaleka okungazelelwe komkhumbi wegazi, okuholela ekulimaleni kwe-ischemic endaweni ethintekile. Esigabeni esibucayi, le ndawo eyinhloko ye-hypoxic idala ukuqubuka kwe-excitotoxicity, ingcindezi ye-oxidative, nokusebenza kwe-microglia, okuholela ekufeni kwe-neuronal. Phakathi nesigaba se-subacute, ukukhishwa kwama-cytokines, ama-chemokines, nama-matrix metalloproteinases (MMPs) kungaba nomthelela ekuvuvukeni kwe-neuroinflammation. Ngokuphawulekayo, amazinga aphakeme we-MMPs akhulisa ukufinyeleleka kwesithiyo sobuchopho-gazi (BBB), okuvumela ukufuduka kwe-leukocyte endaweni ye-infarcted, okwandisa umsebenzi wokuvuvukala.
Ukwelashwa Kwamanje Kwe-Ischemic Stroke
Izindlela zokwelapha ezisebenzayo ze-AIS zihlanganisa i-thrombolysis kanye ne-thrombectomy. I-thrombolysis ye-intravenous ingazuzisa iziguli phakathi namahora angu-4.5, lapho ukwelashwa kusenesikhathi kuhumusha kube izinzuzo ezinkulu. Uma kuqhathaniswa ne-thrombolysis, i-thrombectomy yemishini inefasitela lokwelapha elibanzi. Ngaphezu kwalokho, izindlela zokwelapha ezingezona ezemithi, ezingezona ezihlaselayo ezifanaukwelashwa nge-oxygen, i-acupuncture, nokuvuselela ugesi kuya ngokuya kuba namandla njengezinye izindlela zokwelapha ezivamile.
Okuyisisekelo kwe-Hyperbaric Oxygen Therapy (HBOT)
Ezingeni lomfutho wolwandle (1 ATA = 101.3 kPa), umoya esiwuphefumulayo uqukethe cishe u-21% komoyampilo. Ngaphansi kwezimo zomzimba, ingxenye ye-oxygen encibilikisiwe ku-plasma incane, cishe u-0.29 mL (0.3%) ku-100 mL wegazi. Ngaphansi kwezimo ze-hyperbaric, ukuphefumula i-100% i-oksijeni kwandisa amazinga e-oksijini ahlakazekile ku-plasma kakhulu-kufika ku-3.26% ku-1.5 ATA kanye ne-5.6% ku-2.5 ATA. Ngakho-ke, i-HBOT ihlose ukuthuthukisa le ngxenye yomoya-mpilo oncibilikisiwe, ngempumeleloukwandisa ukugxila kwe-oxygen kwezicubu ezindaweni ze-ischemic. Ezingcindezini eziphakeme, umoya-mpilo usakazeka kalula ezicutshini ze-hypoxic, ufinyelele amabanga amade okusabalalisa uma kuqhathaniswa nomfutho womoya ovamile.
Kuze kube manje, i-HBOT ibone ukusetshenziswa okusabalele kukho kokubili imivimbo ye-ischemic kanye ne-hemorrhagic. Ucwaningo lubonisa ukuthi i-HBOT inikeza imiphumela ye-neuroprotective ngokusebenzisa izindlela eziningi eziyinkimbinkimbi zamangqamuzana, i-biochemical, ne-hemodynamic, okuhlanganisa:
1. Ukwenyuka komfutho wengxenye ye-arterial oxygen, ukuthuthukisa ukulethwa komoyampilo ezicutshini zobuchopho.
2. Ukuqiniswa kwe-BBB, kunciphisa i-edema yobuchopho.
3. Ukuthuthukiswa kobuchophomicrocirculation, ukuthuthukisa umzimba wobuchopho nokukhiqizwa kwamandla ngenkathi kugcinwa i-homeostasis ye-cell ion.
4. Ukulawulwa kokugeleza kwegazi lobuchopho ukuze kwehle umfutho we-intracranial kanye nokunciphisa ukuvuvukala kobuchopho.
5. Ukunciphisa i-neuroinflammation post-stroke.
6. Ukunciphisa i-apoptosis ne-necrosiskulandela unhlangothi.
7. Ukunciphisa ukucindezeleka kwe-oxidative kanye nokuvinjelwa kokulimala kabusha, okubalulekile ku-stroke pathophysiology.
8. Ucwaningo luphakamisa ukuthi i-HBOT inganciphisa i-vasospasm kulandela ukopha kwe-aneurysmal subarachnoid hemorrhage (SAH).
9. Ubufakazi bubuye busekele inzuzo ye-HBOT ekukhuthazeni i-neurogenesis ne-angiogenesis.
Isiphetho
I-Hyperbaric oxygen therapy inikeza indlela ethembisayo yokwelapha isifo sohlangothi. Njengoba siqhubeka nokuxazulula izinkinga zokuthola isifo sohlangothi, uphenyo olwengeziwe luzodingeka ukuze sithuthukise ukuqonda kwethu isikhathi, umthamo, nezindlela ze-HBOT.
Kafushane, njengoba sihlola izinzuzo ze-hyperbaric oxygen therapy for stroke, kuyacaca ukuthi ukusebenzisa lokhu kwelashwa kunamandla okuguqula indlela esiphatha ngayo ukushaywa kwe-ischemic, ukuletha ithemba kulabo abathintekayo ngalesi simo esishintsha ukuphila.
Uma ungathanda ukuhlola i-hyperbaric oxygen therapy njengendlela yokwelapha engase ibe khona yokululama isifo sohlangothi, sikumema ukuthi uvakashele iwebhusayithi yethu ukuze ufunde kabanzi mayelana namagumbi ethu e-hyperbaric oxygen. Ngohlu lwamamodeli aklanyelwe ukusetshenziswa ekhaya nasemsebenzini, i-MACY-PAN inikeza izixazululo eziletha ukwelapha komoyampilo okusezingeni eliphezulu, okuhlosiwe ukuze kusekelwe uhambo lwakho lwezempilo nokululama.
Zitholele imikhiqizo yethu nokuthi ingathuthukisa kanjani inhlalakahle yakho kwawww.hbotmacypan.com.
Isikhathi sokuthumela: Feb-18-2025